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. Author manuscript; available in PMC: 2020 Jan 2.
Published in final edited form as: Microcirculation. 2016 Feb;23(2):134–145. doi: 10.1111/micc.12248

Figure 4-. Cooperation between H2S and NO in regulating ischemic vascular remodeling.

Figure 4-

Panel A illustrates temporal changes in plasma H2S and NO levels after femoral artery ligation (adapted from references 8 & 53). Plasma H2S levels were found to quickly increase after femoral artery ligation preceding an increase in plasma NO levels, which subsequently return to normal levels after NO bioavailability is increased. Panel B shows molecular and biochemical pathways activated after tissue ischemia that results in activation of arteriogenesis and angiogenesis responses in the femoral artery ligation model.