Table 1.

NADPH oxidase inhibitors

Compound	Mechanism of action	Chemical name	Chemical structure	Target	References
GKT137981	Dual Nox1/4 inhibitor	2-(2-Chlorophenyl)-4-(3-dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c] pyridine-3,6(2H,5H)-dione		Liver fibrosis, kidney fibrosis, lung fibrosis	Laleu et al., 2010; Gaggini et al., 2011; Aoyama et al., 2012; Green et al., 2012; Jha et al., 2014; Gorin et al., 2015; Jha et al., 2016
APX-115	Pan-Nox inhibitor	3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-olhydrochloride		Diabetic Nephropathy	Cha et al., 2017; Kwon et al., 2017; Dorotea et al., 2018