Table 1.
Measures | Week 20 immediate vs. Week 20 gradual | Week 4 immediate vs. Week 20 gradual | ||
---|---|---|---|---|
Mean difference Immediate vs. gradual (95% CI) | p | Mean difference Immediate vs. gradual (95% CI) | p | |
Satisfaction | −1.00 (−1.21 to −0.80) | <.00001* | −0.67 (−0.88 to −0.45) | <.00001* |
Psych reward | −0.52 (−0.68 to −0.36) | <.00001* | −0.23 (−0.38 to −0.08) | .0025* |
Aversion | 0.02 (−0.09 to 0.13) | 0.75 | 0.08 (−0.04 to 0.20) | 0.20 |
Enjoy sensation | −0.63 (−0.84 to −0.42) | <.00001* | −0.48 (−0.70 to −0.26) | <.0001* |
Craving relief | −0.87 (−1.15 to −0.60) | <.00001* | −0.49 (−0.77 to −0.22) | .0006* |
Bolded p values with asterisks indicate significance. Linear regression adjusted for baseline mCEQ subscale score (usual brand). Missing data were imputed by multiple imputation method. CI = confidence interval; Enjoy sensation = Enjoyment of Respiratory Tract Sensations; Psych reward = Psychological Reward.