Table 2.
Results of Linear Regression Analyses Testing for Effects of Cigarette Condition (0.4 mg/g Nicotine–15.8 mg/g Nicotine) at Week 6 Unadjusted (Baseline Only) and Adjusted for Gender, Age, and Baseline Levels of Each Variable
| Unadjusted linear regression | Adjusted linear regression | |||
|---|---|---|---|---|
| Mean difference (95% CI) | p-value | Mean difference (95% CI) | p-value | |
| Total cigarettes per day | –4.01 (–8.25 to 0.22) | .063 | –4.23 (–8.40 to –0.06) | .047 |
| Study cigarettes per day | –9.57 (–15.43 to –3.72) | .002 | –9.96 (–15.59 to –4.34) | <.001 |
| Non-study cigarettes per day | 5.56 (1.60 to 9.52) | .007 | 5.73 (1.81 to 9.65) | .005 |
| Carbon monoxide level (ppm) | –4.93 (–9.49 to –0.37) | .035 | –5.29 (–9.80 to –0.79) | .022 |
| TNE (nmol/mg creatinine) | 0.86 (0.43 to 1.72) | .658 | 0.86 (0.42 to 1.75) | .678 |
| NNAL (nmol/mg creatinine) | 1.19 (0.73 to 1.96) | .470 | 1.16 (0.70 to 1.92) | .545 |
| FTCD | –0.49 (–1.39 to 0.41) | .282 | –0.51 (–1.40 to 0.39) | .262 |
| QSU total (study brand) | –9.47 (–17.88 to –1.07) | .028 | –9.76 (–18.42 to –1.09) | .028 |
| MNWS | 0.36 (–2.62 to 3.33) | .810 | 0.56 (–2.42 to 3.54) | .707 |
| CES Satisfaction | –4.96 (–7.42 to –2.51) | <.001 | –5.03 (–7.52 to –2.54) | <.001 |
| CES Psychological Reward | –4.19 (–7.67 to –0.72) | .019 | –3.98 (–7.52 to –0.44) | .028 |
| CES Enjoyment of Sensations | –0.97 (–1.89 to –0.05) | .039 | –0.95 (–1.88 to –0.02) | .046 |
| CES Craving Reduction | –1.42 (–2.41 to –0.43) | .006 | –1.40 (–2.41 to –0.38) | .008 |
| CES Aversion | 0.04 (–1.24 to 1.32) | .954 | 0.06 (–1.24 to 1.37) | .923 |
| PANAS Positive Affect | 0.40 (–3.71 to 4.51) | .845 | 0.14 (–3.93 to 4.21) | .945 |
| PANAS Negative Affect | –1.16 (–5.17 to 2.85) | .563 | –1.34 (–5.37 to 2.69) | .507 |
| PANSS Positive Symptoms | 0.05 (–1.46 to 1.57) | .945 | –0.01 (–1.53 to 1.50) | .985 |
| PANSS Negative Symptoms | –0.10 (–2.11 to 1.91) | .920 | –0.03 (–2.03 to 1.98) | .979 |
| PANSS General Symptoms | –0.27 (–2.72 to 2.18) | .826 | –0.27 (–2.72 to 2.18) | .826 |
| SANS | –1.19 (–6.47 to 4.09) | .651 | –0.99 (–6.27 to 4.28) | .706 |
| Brief Psychiatric Rating Scale | –0.15 (–2.70 to 2.40) | .905 | 0.09 (–2.55 to 2.74) | .945 |
| Calgary Depression Scale | 0.22 (–1.23 to 1.67) | .759 | 0.21 (–1.24 to 1.66) | .768 |
| CES-D | 2.02 (–2.54 to 6.59) | .377 | 1.88 (–2.71 to 6.46) | .413 |
| AIMS | 0.18 (–0.41 to 0.77) | .537 | 0.21 (–0.38 to 0.80) | .473 |
| Barnes Akathisia Scale | 0.15 (–0.24 to 0.54) | .435 | 0.17 (–0.22 to 0.56) | .387 |
| Simpson-Angus Scale | –0.77 (–1.37 to –0.17) | .013 | –0.77 (–1.39 to –0.15) | .016 |
TNE, total nicotine equivalents; FTCD, Fagerström Test of Cigarette Dependence; QSU, Questionnaire on Smoking Urges; MNWS, Minnesota Nicotine Withdrawal Scale; CES, Cigarette Evaluation Scales; PANAS, Positive and Negative Affect Schedule; PANSS, Positive and Negative Syndrome Scale; SANS, Scale for Assessment of Negative Symptoms; CES-D, Center for Epidemiologic Studies Depression Scale; AIMS, Abnormal Involuntary Movements Scale