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. 2019 Dec 16;3(4):1–6. doi: 10.1093/ehjcr/ytz225
Events
2 months prior to autologous peripheral blood stem cell transplantation (auto-PBSCT) Patient admitted to our hospital for dyspnoea, progressive anaemia, and decreased appetite
Transthoracic echocardiography led us to strongly suspect cardiac amyloidosis (CA) with heart failure
1 month prior to auto-PBSCT Diagnosed with light-chain CA
BD treatment (bortezomib + dexamethasone) and medical treatment was started
February 2014 High-dose chemotherapy (melphalan, 140 mg/m2) with auto-PBSCT was started
Brain natriuretic peptide (BNP) = 1194 pg/mL, global longitudinal strain (GLS) = −6.2%, and left ventricular (LV) wall = 14 mm
4 months after auto-PBSCT Symptoms were getting relieved and discharged hospital
BNP levels declined to the 700s pg/mL
6 months after auto-PBSCT BNP levels declined to the 200s pg/mL
GLS showed only a slight change (−8.3%)
11 months after auto-PBSCT BNP levels declined to the 80s pg/mL
GLS improved to a value of −12.2%
LV wall showed only a slight change (12 mm)
22 months after auto-PBSCT BNP levels normalized.
GLS improved to a value of −16.2%
LV wall improved to 10 mm
60 months after auto-PBSCT Patient has been no relapse and continues to visit the outpatient clinic.