2 months prior to autologous peripheral blood stem cell transplantation (auto-PBSCT) |
Patient admitted to our hospital for dyspnoea, progressive anaemia, and decreased appetite |
Transthoracic echocardiography led us to strongly suspect cardiac amyloidosis (CA) with heart failure |
1 month prior to auto-PBSCT |
Diagnosed with light-chain CA |
BD treatment (bortezomib + dexamethasone) and medical treatment was started |
February 2014 |
High-dose chemotherapy (melphalan, 140 mg/m2) with auto-PBSCT was started |
Brain natriuretic peptide (BNP) = 1194 pg/mL, global longitudinal strain (GLS) = −6.2%, and left ventricular (LV) wall = 14 mm |
4 months after auto-PBSCT |
Symptoms were getting relieved and discharged hospital |
BNP levels declined to the 700s pg/mL |
6 months after auto-PBSCT |
BNP levels declined to the 200s pg/mL |
GLS showed only a slight change (−8.3%) |
11 months after auto-PBSCT |
BNP levels declined to the 80s pg/mL |
GLS improved to a value of −12.2% |
LV wall showed only a slight change (12 mm) |
22 months after auto-PBSCT |
BNP levels normalized. |
GLS improved to a value of −16.2% |
LV wall improved to 10 mm |
60 months after auto-PBSCT |
Patient has been no relapse and continues to visit the outpatient clinic. |