Table 1. Regulatory roles of PIP and IP enzymes in T. brucei.

Gene ID	Enzyme	Regulatory process	Localization	Reference
Tb927.4.1620	PIP5K	VSG gene exclusive expression and switching	Plasma membrane and endosomes	[7]
Tb927.11.6270	PIP5Pase	VSG gene exclusive expression	Nucleus	[5, 7]
Tb927.11.5970	PLC	VSG gene exclusive expression	Plasma membrane	[7]
Tb927.9.12470	IPMK	Metabolic switch from glycolysis to oxphos and development of BFs to PFs	Plasma membrane and cytosol	[6]
Tb927.8.2770	IP3RyR	Intracellular Ca2+ from acidocalcisomes	Acidocalcisomes	[12]
Tb927.4.1140	PI4K	Protein trafficking and Golgi maintenance and structure	Golgi complex	[11]
Tb927.8.6210	PI3K	Golgi complex segregation	Golgi complex	[10]
Tb927.11.1460	PI3P5K	Protein trafficking and multivesicular body degradation	Endosome and lysosomes	[9]

Gene IDs are from TriTrypDB. IP3RyR, inositol trisphosphate/ryanodine receptor; IPMK, inositol polyphosphate multikinase; PI3K, phosphatidylinositol 3-kinase; PI3P5K, phosphatidylinositol 3-phosphate 5-kinase; PI4K, phosphatidylinositol 4-kinase; PIP5K, phosphatidylinositol phosphate 5-kinase; PIP5Pase, phosphatidylinositol phosphate 5-phosphatase; PLC, phospholipase C