Table 2:

Time Within, Below, and Above Target Glucose Range, Hypoglycemia Events, Glucose Variability for Type 1 Diabetes

Group Mean				Difference Between Flash and SMBG, % Change	Difference in Adjusted Means Between Flash and SMBG (95% CI)a	P Value
Flash		SMBG
Baseline	Study End	Baseline	Study End
Hours in target glucose range (3.9–10.0 mmol/L) within 24 hours
15.0	15.8	14.8	14.6	NA	1.0 (0.41 to 1.59)	.0006
Hours above target glucose range (> 13.3 mmol/L) within 24 hours
1.84	1.67	1.91	2.06	−19.1%	−0.37 (−0.69 to −0.05)	.0247
Hours in hypoglycemia (< 3.9 mmol/L) within 24 hours
3.38	2.03	3.44	3.27	−38.0%	−1.24 (−1.71 to −0.77)	< .0001
Hours in hypoglycemia at night (11 pm-6 am) within 7 hours
1.32	0.68	1.48	1.23	−39.8%	−0.47 (−0.70 to −0.24)	< .0001
Mean no. of hypoglycemia events < 3.9 mmol/L (70 mg/dL) within 24 hours
1.81	1.32	1.67	1.69	−25.8%	−0.45 (−0.62 to −0.28)	< .0001
Mean amplitude of glucose excursionb
142	132	144	141	NA	−8.0 (−13.88 to −2.12)	.0004
Blood glucose risk index, mg/dLb
8.2	7.3	8.3	8.4	NA	−0.90 (−1.41 to −0.39)	.0004
Coefficient of variation in glucose, %b
43.0	37.6	42.5	41.8	NA	−4.4 (−5.62 to −3.18)	< .0001
Low blood glucose risk indexb
2.7	1.8	2.7	2.6	NA	−0.8 (−1.11 to −0.49)	< .0001
Standard deviation of glucose, mg/dLb
60.6	55.0	60.1	59.7	NA	−5.0 (−7.27 to −2.73)	< .0001
Continuous overlapping net glycemic action, 2 hours, mg/dLb
56	49	56	58	NA	−9 (−11.55 to −6.45)	< .0001
Continuous overlapping net glycemic action, 6 hours, mg/dLb
71	61	69	72	NA	−12 (−18.66 to −5.34)	.0004

Abbreviations: CI, confidence interval; NA, not applicable; SMBG, self-monitoring of blood glucose.

^aConfidence intervals were computed by the authors of this health technology assessment using standard errors reported in the primary study.

^bA scale for measuring glucose variability.

Source: Bolinder et al.³²