Table 8:
Group Means | Difference Between Flash and SMBG (% Change) | Difference in End-of-Study Adjusted Means Between Flash and SMBG (95% CI) | P Value | |||
---|---|---|---|---|---|---|
Flash | SMBG | |||||
Baseline | Study End | Baseline | Study End | |||
Hours in target glucose range (3.9–10.0 mmol/L) within 24 hours | ||||||
13.9 | 13.6 | 13.5 | 13.2 | 1.1% | 0.2 (−0.94, 1.34) | .7925 |
Hours above target glucose range (> 13.3 mmol/L) within 24 hours | ||||||
3.1 | 3.5 | 3.9 | 3.9 | 2.1% | 0.1 (−0.80 to 1.00) | .8729 |
Hours in hypoglycemia (< 3.9 mmol/L) within 24 hours | ||||||
1.3 | 0.59 | 3.44 | 3.27 | −38.0% | −1.24 (−1.71 to −0.77) | < .0001 |
Hours in hypoglycemia at night (11 pm-6 am) within 7 hours | ||||||
0.55 | 0.23 | 0.49 | 0.51 | −54.3% | −0.29 (−0.45, −0.13) | .0001 |
Mean hypoglycemia events < 3.9 mmol/L (70 mg/dL) within 24 hours | ||||||
0.64 | 0.38 | 0.63 | 0.53 | 27.7% | −0.16 (−0.29 to −0.03) | .0164 |
Hours in hyperglycemia (> 13.3 mmol/L) within 24 hours | ||||||
3.1 | 3.5 | 3.9 | 3.9 | 2.1% | 0.1 (−0.80, 1.00) | .8729 |
Mean amplitude of glucose excursiona | ||||||
128 | 125 | 131 | 131 | NA | −4.0 (−10.47 to −2.47) | .1909 |
Blood glucose risk indexa | ||||||
9.5 | 9.9 | 10.4 | 10.5 | NA | 0.0 (−1.37 to 1.37) | .9431 |
Coefficient of variation in glucose, %a | ||||||
34.1 | 31.4 | 33.1 | 33.0 | NA | −2.26 (−3.65 to −0.868) | .0017 |
Low blood glucose risk indexa | ||||||
1.1 | 0.60 | 1.0 | 0.90 | NA | −0.30 (−0.52 to −0.08) | .0029 |
Standard deviation of glucose, mg/dLa | ||||||
56 | 54 | 56 | 56 | NA | −1.67 (−4.51 to −1.17) | .2538 |
Continuous overall net glycemic action, 2 hours, mg/dLa | ||||||
49 | 47 | 50 | 51 | NA | −3.0 (−5.55 to −0.45) | .0385 |
Continuous overall net glycemic action, 4 hours, mg/dLa | ||||||
61 | 57 | 61 | 64 | NA | −5.0 (−9.31 to −0.69) | .0133 |
Continuous overall net glycemic action, 6 hours, mg/dLa | ||||||
63 | 58 | 62 | 65 | NA | −8.0 (−13.88 to −2.12) | .0046 |
Abbreviations: CI, confidence interval; NA, not applicable; SMBG, self-monitoring of blood glucose.
A scale for measuring glucose variability.
Source: Haak et al.33