Table A1:

Risk of Bias^a Among Randomized Controlled Trials (Cochrane Risk of Bias Tool)

Author, Year	Random Sequence Generation	Allocation Concealment	Blinding of Participants and Personnel	Incomplete Outcome Data	Selective Reporting	Other Bias
Bolinder et al, 201632	Low risk; participants were randomized using a computer random number generator	Low risk; there is no indication that intervention allocations could have been foreseen before or during enrolment	Low risk; although participants were not blinded on intervention, it is unlikely that lack of blinding affected treatment adherence or resulted in differential care	High risk; missing data were imputed by the last observation carried forward for the primary endpoint. This could have induced outcome misclassification and underestimation of random errors	Unknown risk	Low risk for the influence of flash inaccuracy on hypoglycemic outcomes based on the findings from quantitative bias analysis
Haak et al, 201633	Low risk; participants were randomized using a computer random number generator	Low risk; there is no indication that intervention allocations could have been foreseen before or during enrolment	Low risk; although participants were not blinded on intervention, it is unlikely that lack of blinding affected treatment adherence or resulted in differential care	High risk; missing data were imputed by the last observation carried forward for the primary endpoint. This could have induced outcome misclassification and underestimation of random errors	Unknown risk	Low risk for the influence of flash inaccuracy on hypoglycemic outcomes based on the findings from quantitative bias analysis

^aPossible risk-of-bias levels: low, high, and unclear.