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. Author manuscript; available in PMC: 2020 Jun 15.
Published in final edited form as: Clin Cancer Res. 2019 Sep 23;25(24):7506–7516. doi: 10.1158/1078-0432.CCR-19-1479

FIGURE 5:

FIGURE 5:

Trispecific CAR G3-Ec1-E01 T cells demonstrate synergy against tumor cells expressing multiple antigens. (A) Bioluminescence imaging of tumors expressing single (EGFR, EpCAM or HER2) antigens or both HER2 and EpCAM in mice treated with 9 million trispecific CAR-T cells. (B) Survival curves of cohorts of mice after treatment with 9 million trispecific CAR-T cells. (C) Bioluminescence imaging of tumors expressing single, double or all 3 antigens (EGFR, HER2 and EpCAM) in mice treated with 5 million trispecific CAR-T cells. (D) Survival curves of cohorts of mice after treatment with 5 million trispecific CAR-T cells. (**-p<0.05, ns-not significant)