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. 2019 Sep 27;161(1):74–82. doi: 10.1097/j.pain.0000000000001707

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 6. — (A) Regression between GABA_A receptor concentration and current pain level (CPL). Whole-brain map of the positive association between GABA_A receptor concentration (flumazenil BP_ND) and current pain level across all subjects. T-values are presented at a voxel-wise threshold of P < 0.001 and cluster-extent threshold of k > 53, overlaid on the mean anatomical image of the whole sample (N = 51). Axial images are displayed in neurological convention, ie, the left hemisphere is on the left. (B) Scatter plot of GABA_A receptor concentration extracted from the insular cluster and current pain level. The insular cluster was chosen because of the highest T-value in the group comparison; the scatter plot only serves to illustrate the positive association between flumazenil BP_ND and current pain level for the whole sample. FM, patients with fibromyalgia.