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. 2019 Nov 20;132(22):2716–2723. doi: 10.1097/CM9.0000000000000513

Figure 2.

Figure 2

Effects of endostatin overexpression on cardiac hypertrophy in Ang II-treated rats. (A) Endostatin overexpression attenuated the increases in HW, HW/BW and HW/TL in Ang II-treated rats. (B) Representative photographs with heart tissue sections in four groups (hematoxylin-eosin staining, bar: 1 mm). (C) Endostatin overexpression attenuated the increase in cardiomyocyte cross-sectional area in Ang II-treated rats (hematoxylin-eosin staining, bar: 50 μm). (D) Endostatin overexpression reduced the increase in ANP and BNP mRNA levels in Ang II-treated rats. Results are expressed as mean ± SE, n = 6. ∗P < 0.05 vs. the Ad-GFP group; †P < 0.05 vs. the Ad-endostatin group. Ad-GFP group: Rats treated with adenovirus expressing green fluorescent protein; Ang II group: Rats treated with Ang II; Ad-endostatin group: Rats treated with adenovirus expressing endostatin; Ang II + Ad-endostatin group: Rats treated with Ang II and adenovirus expressing endostatin. Ad-GFP: Adenovirus-green fluorescent protein; Ang II: Angiotensin II; ANP: Atrial natriuretic peptide; BNP: Brain natriuretic peptide; BW: Body weight; HW: Heart weight; mRNA: Messenger RNA; TL: Tibial length; SE: Standard error.