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. 2019 Nov 20;132(22):2716–2723. doi: 10.1097/CM9.0000000000000513

Figure 4.

Figure 4

Effects of endostatin overexpression on hypertrophy in Ang II-treated primary cardiomyocytes. (A) Endostatin overexpression attenuated the increase in cardiomyocyte size in Ang II-treated cardiomyocytes (Immunofluorescence, Bar: 100 μm). (B) Endostatin overexpression reduced the increase in ANP and BNP mRNA and protein levels in Ang II-treated cardiomyocytes. Results are expressed as mean ± SE, n = 6. ∗P < 0.05 vs. the Ad-GFP group; †P < 0.05 vs. the Ad-endostatin group. Ad-GFP group: Cardiomyocytes treated with adenovirus expressing green fluorescent protein; Ang II group: Cardiomyocytes treated with Ang II; Ad-endostatin group: Cardiomyocytes treated with adenovirus expressing endostatin; Ang II + Ad-endostatin group: Cardiomyocytes treated with Ang II and adenovirus expressing endostatin. Ad-GFP: Adenovirus-green fluorescent protein; Ang II: Angiotensin II; ANP: Atrial natriuretic peptide; BNP: Brain natriuretic peptide; mRNA: Messenger RNA; SE: Standard error.