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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Nat Cell Biol. 2019 Nov 4;21(11):1321–1333. doi: 10.1038/s41556-019-0402-6

Extended Data Figure 7. Treatment with Rapamycin impairs organoid formation.

Extended Data Figure 7

a, EpCAM+ ductal cells freshly isolated from the undamaged liver were treated at 0-18hrs or 18-48hrs with the indicated small molecule inhibitors. Organoid formation was quantified at day 6. Graph represents organoid formation efficiency and indicates mean ±SD of n=3 independent experiments. Statistical analyses were performed with two-ways ANOVA with Bonferroni’s multiple compared test (vs DMSO control group). DMSO control quantifications are shown in Fig. 6f. Representative pictures of organoids treated with the inhibitors at 18-48hrs are shown.