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. 2020 Jan 2;4:1. doi: 10.1038/s41538-019-0061-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Effect of increasing dietary linoleic acid (LA) on unesterified oxidized linoleic acid metabolite (OXLAM) concentrations in rat cerebral cortex. Adapted from Taha et al.,³¹ EpOME epoxyoctadecamonoenoic acid, THF tetrahydrofuran-diols, EKODE epoxyketooctadecenoic acid, HODE hydroxyoctadecadienoic acid, oxo-ODE Oxo-octadecadienoic acid, DiHOME dihydroxyoctadecamonoenoic acid, TriHOME trihydroxyoctadecamonoenoic acid. Data are graphed as median and interquartile interval (IQR) representing the 25th and 75th percentiles. *p < 0.05 compared to 0.4% LA group by Kruskall–Wallis test.