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. 2020 Jan 2;11:63. doi: 10.1038/s41467-019-13710-4

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

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Fig. 9 — a, b Quantification of head tremor for P9 pups. The number of bouts normalized over a 100 mm distance traveled (a) and average duration of each head-tremor episode over a 10-min period are shown (b). Cyp26b1 cKO pups showed more frequent (a, 4.8 ± 1.1 in mutants, n = 6, vs. 1.2 ± 0.2 in controls, n = 8, P = 0.0059) and longer duration (b, 398 ± 38 ms in mutants vs. 192 ± 9 ms in controls, n = 8, P < 0.0001) head tremor, compared to Foxg1^Cre;Cyp26b1^lox/+ controls. c Schematic of the apparatus for measuring head tremor of an adult mouse at rest with a miniture head motion sensor affixed on the top of the skull. d Cyp26b1 cKO showed characteristic head tremor (5/6), which were not present in controls. e, f Comparison of power spectra density of head movements in translational axes (e) and rotational axes (f) between controls (blue) and Cyp26b1 cKO mutants (red). Cyp26b1 cKO exhibit siginificantly higher power than controls at high frequencies (5–20 Hz, P = 0.006 for right/left, P = 0.005 for fore/aft, P = 0.01 for up/down, P = 0.035 for pitch, P = 0.014 for roll, and P = 0.011 for yaw axis, n = 6/group). Angular head velocity for yaw and roll axes of Cyp26b1 cKO also had significantly higher power for frequencies between 1 and 5 Hz (upper graphs, P = 0.05 for yaw and P = 0.028 for roll axis). Unpaired t test was applied for all panels. Error bars: SEM. *P < 0.05, **P < 0.01, and ***P < 0.001.