Fig. 6.

Oxcarbazepine (OXC) inhibited Na⁺ channel currents of hNav1.7 and SCN9A variants and modulates the steady-state activation. A Average Na⁺ current traces recorded from HEK293T cells co-expressing pEZ-Lv206-hNav1.7 and pIRES-EGFP-hβ1 plasmids and treated with OXC. B Scatter plots showing the normalized macroscopic current amplitude remaining after blockade by OXC (120 μmol/L). C–F Left, shifts in the voltage-dependence of steady-state activation for WT (C), N641Y (D), K655R (E), and W1150R (F) following treatment with OXC (120 μmol/L). Curves are Boltzmann fits. Right, scatter plots of voltage at half-maximal steady-state inactivation (V_1/2). Data are the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. Black, no drug treatment; red, treated with OXC.