Table 2.

Oxcarbazepine (OXC, 120 μmol/L) modulated the biophysical properties of mutant and WT channels.

	Activation			Steady inactivation			Fast inactivation			Recovery from fast inactivation
	V1/2 (mV)	K	n	V1/2 (mV)	K	n	V1/2 (mV)	K	n	τ (ms)	n
WT	− 19.5 ± 0.7	3.3 ± 0.1	8	− 66.3 ± 0.6	5.6 ± 0.3	9	− 38.0 ± 0.4	8.5 ± 0.3	7	1.7 ± 0.3	12
WT + OXC	− 23.6 ± 1.2**	3.7 ± 0.2	8	− 71.7 ± 1.5**	5.8 ± 0.2	9	− 46.1 ± 1.5***	8.8 ± 0.5	7	2.5 ± 0.2**	17
N641Y	− 17.0 ± 0.8	3.6 ± 0.4	6	− 62.7 ± 1.1	6.5 ± 0.1	14	− 37.1 ± 0.9	5.5 ± 0.3	9	1.3 ± 0.1	8
N641Y + OXC	− 24.6 ± 0.6***	3.7 ± 0.2	6	− 69.1 ± 1.4**	6.7 ± 0.4	14	− 46.4 ± 2.1***	4.9 ± 0.8	9	2.8 ± 0.3***	8
K655R	− 17.8 ± 1.8	3.5 ± 0.3	9	− 67.9 ± 0.3	5.1 ± 0.2	11	− 37.0 ± 0.9	8.1 ± 0.5	13	1.4 ± 0.1	17
K655R + OXC	− 24.3 ± 0.7*	3.6 ± 0.4	12	− 71.3 ± 0.7***	6.1 ± 0.2**	11	− 41.5 ± 1.2**	8.5 ± 0.5	13	1.8 ± 0.1**	16
W1150R	− 23.7 ± 1.9	2.8 ± 0.3	12	− 64.5 ± 0.5	5.6 ± 0.2	10	− 37.5 ± 1.3	8.9 ± 1.3	9	2.4 ± 0.2	11
W1150R + OXC	− 31.2 ± 2.5*	2.9 ± 0.4	12	− 73.1 ± 2.0***	6.1 ± 0.3	10	− 50.3 ± 2.3***	8.9 ± 1.0	9	3.2 ± 0.3*	11

V_1/2, voltage midpoint activation or inactivation; K, slope factor; n, number of cells; τ, time constant.

Values represent the mean ± SEM.

*P < 0.05, **P < 0.01, ***P < 0.001, unpaired Student’s t-test.