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(A) Morphological analysis of HepG2 (P) and HepG2 (R) cells. (B) Sorafenib dose response curve [IC50 HepG2 (P) = 1.6 μM; IC50 HepG2 (R) = 3.6 μM; fold resistance = 2.25]. HepG2 (P), HepG2 parental; HepG2 (R), HepG2 sorafenib-resistant; Conc., concentrations.
