Fig. 3. Effects of CAR on memory impairment in the ORT and MWM test.

The ability to discriminate between familiar objects (A) and new objects (B) in the ORT. The MWM test was used to assess the effect of CAR on spatial learning and memory. The time taken to escape from water (latency) during acquisition trials using a submerged platform (C), the percentages of time spent in the target quadrant and the proportion of the total distance traversed in the target quadrant (D), and swimming speed (E) in the MWM test. Locomotor activity (counts) and total number of rearings (G) in the OFT (n = 10–12/group). CAR, carvacrol; ORT, object recognition test; MWM, Morris water maze; OFT, open field test; LPS, lipopolysaccharide; SAL, saline-treated; IBU, ibuprofen. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. SAL group; ^#p < 0.05, ^##p < 0.05 vs. LPS group.