Table 3:

Sero-positivity to H. pylori proteins in relation to active H. pylori infection determined by UBT, DISH (training set) and HSS (validation set).

N positive	Training set (DISH) n=58 UBT (−), n=20 UBT (+)				Validation set (HSS) n=39 UBT (−), n=10 UBT (+)
proteins	Specificity	95% CI	Sensitivity	95% CI	Specificity	95% CI	Sensitivity	95% CI
Among all 13 proteins
≥ 1	59	46–71	100	100–100	59	44–74	100	100–100
≥ 2	78	67–88	100	100–100	74	61–88	100	100–100
≥ 3	86	77–95	100	100–100	90	80–99	100	100–100
≥ 4	86	77–95	100	100–100	92	84–100	100	100–100
≥ 5	95	89–100	90	77–100	92	84–100	100	100–100
≥ 6	98	95–100	80	62–98	92	84–100	70	42–98
≥ 7	98	95–100	70	50–90	95	88–100	50	19–81
≥ 8	100	100–100	65	44–86	95	88–100	40	10–70
Among VacA, GroEl, HcpC, HP1564
≥ 1	76	65–87	100	100–100	85	73–96	100	100–100
≥ 2	90	82–97	100	100–100	92	84–100	100	100–100
≥ 3	100	100–100	85	69–100	92	84–100	100	100–100
= 4	100	100–100	65	44–86	97	92–100	50	19–81

Abbreviations: (−), Negative; (+), Positive; CI: confidence interval; DISH: Durham Initiative for Stomach Health; HSS: Healthy Stomach Study; UBT, Urea breath test