Table 4.

Factors associated with day 28 CR/PR, 2 year mortality and TRM: Multivariate analysis

Factors	Odds ratio of CR/PR (95% CI)	P	HR of mortality (95% CI)	P	HR of TRM (95% CI)	P
Minnesota GVHD risk
Standarda	1.0		1.0		1.0
High	0.4 (0.2–0.7)	<0.01	1.4 (0.9–2.2)	0.11	1.7 (1.0–2.7)	0.03
Donor type		<0.01		<0.01		<0.01
Matched/MM siblinga	1.0		1.0		1.0
URD well matched	1.5 (0.7–3.4)	0.31	1.5 (0.8–2.6)	0.22	1.8 (0.9–3.6)	0.10
URD partial matched	0.9 (0.4–1.9)	0.78	1.9 (1.1–3.4)	0.02	2.1 (1.1–4.0)	0.03
URD mismatched	0.4 (0.2–0.9)	0.02	2.4 (1.4–4.0)	<0.01	2.9 (1.6–5.2)	<0.01
UCB	1.7 (0.9–3.3)	0.10	1.2 (0.7–2.0)	0.41	1.0 (0.5–1.8)	0.92

^aReference group

Factors tested included all factors from univariate in a backward selection only keeping factors with overall p < 0.10 in final model. Organ involvement and grade of acute GVHD were not included due to collinearity with “new risk”. Lansky/Karnofsky was not included due to too many missing values. Age was treated as a continuous factor. Standard-risk disease includes acute leukemia/NHL in CR1 or CR2, CML in 1st chronic phase, MDS without excess blasts. High risk disease includes all others.

The Minnesota GVHD Risk Score was predictive of response regardless of transplant era