Figure 3. Siplizumab lymphodepleting effect varies among different CD8⁺ and CD4⁺ FoxP3⁻ T-cell subsets in allogeneic HLA-mismatched MLRs.

CD8⁺ (A) and CD4⁺ FoxP3⁻ (B) T-cell subsets recovered from the HLA-mismatched MLRs expressed both as percentage of total CD3⁺ responders and as absolute cell numbers (median [IQR]); n = 10 unique donor pairs. Red-colored symbol: p < 0.05 compared to No drug MLR (repeated-measures ANOVA and Dunnet’s multiple comparisons test, or Friedman’s test and Dunn’s multiple comparisons tests, as appropriate).