Table 1.
Treatment Prescribed at Index | No Antibiotics N (%) |
Oral and/or Inhaled Antibiotics N (%) |
IV AntibioticsaN (%) |
Overall N (%) |
---|---|---|---|---|
Number of Patients (%) | 3,059 (21.4%) | 8,774 (61.5%) | 2,432 (17.0%) | 14,265 |
Age Group (years) | ||||
<6 | 663 (21.7%) | 1631 (18.6%) | 199 (8.2%) | 2493 (17.5%) |
6 to <13 | 592 (19.4%) | 2264 (25.8%) | 395 (16.2%) | 3251 (22.8%) |
13 to <18 | 436 (14.3%) | 1512 (17.2%) | 453 (18.6%) | 2401 (16.8%) |
18 to <26 | 594 (19.4%) | 1601 (18.2%) | 629 (25.9%) | 2824 (19.8%) |
≥26 | 774 (25.3%) | 1766 (20.1%) | 756 (31.1%) | 3296 (23.1%) |
Female | 1483 (48.5%) | 4352 (49.6%) | 1323 (54.4%) | 7158 (50.2%) |
Race | ||||
Caucasian | 2881 (94.2%) | 8221 (93.7%) | 2292 (94.2%) | 13394 (93.9%) |
African American | 100 (3.3%) | 329 (3.7%) | 75 (3.1%) | 504 (3.5%) |
Other | 78 (2.5%) | 224 (2.6%) | 65 (2.7%) | 367 (2.6%) |
Hispanic Ethnicityb | 267 (9.0%) | 692 (8.2%) | 206 (8.7%) | 1165 (8.5%) |
Insurance Status | ||||
Private | 1869 (61.1%) | 5251 (59.8%) | 1266 (52.1%) | 8386 (58.8%) |
Medicare/Medicaid | 1117 (36.5%) | 3342 (38.1%) | 1106 (45.5%) | 5565 (39.0%) |
Other | 17 (0.6%) | 62 (0.7%) | 26 (1.1%) | 105 (0.7%) |
Missing | 56 (1.8%) | 119 (1.4%) | 34 (1.4%) | 209 (1.5%) |
Nutrition Status | ||||
Underweight | 261 (8.5%) | 720 (8.2%) | 417 (17.1%) | 1398 (9.8%) |
Adequate | 1962 (64.1%) | 6025 (68.7%) | 1649 (67.8%) | 9636 (67.5%) |
Overweight | 483 (15.8%) | 1280 (14.6%) | 236 (9.7%) | 1999 (14.0%) |
Missing | 353 (11.5%) | 749 (8.5%) | 130 (5.3%) | 1232 (8.6%) |
Time from Baseline to Index Clinic Visit (days) | ||||
≤30 | 475 (15.5%) | 964 (11.0%) | 535 (22.0%) | 1974 (13.8%) |
31 to 90 | 1256 (41.1%) | 3665 (41.8%) | 1149 (47.2%) | 6070 (42.6%) |
≥91 | 1328 (43.4%) | 4145 (47.2%) | 748 (30.8%) | 6221 (43.6%) |
CF-related Diabetes | 539 (17.6%) | 1407 (16.0%) | 731 (30.1%) | 2677 (18.8%) |
CFTR Mutation Class | ||||
Only 1 to 3 | 2136 (69.8%) | 6478 (73.8%) | 1864 (76.6%) | 10478 (73.5%) |
Any 4 and 5 | 294 (9.6%) | 695 (7.9%) | 157 (6.5%) | 1146 (8.0%) |
Other | 559 (18.3%) | 1443 (16.4%) | 364 (15.0%) | 2366 (16.6%) |
Unknown | 70 (2.3%) | 158 (1.8%) | 47 (1.9%) | 275 (1.9%) |
FEV1 % Predicted at Index | ||||
Not Applicable <6 years old | 663 (21.7%) | 1631 (18.6%) | 199 (8.2%) | 2493 (17.5%) |
≤40 | 279 (9.1%) | 634 (7.2%) | 572 (23.5%) | 1485 (10.4%) |
41 to ≤70 | 678 (22.2%) | 2068 (23.6%) | 863 (35.5%) | 3609 (25.3%) |
71 to ≤100 | 970 (31.7%) | 3069 (35.0%) | 513 (21.1%) | 4552 (31.9%) |
>100 | 237 (7.7%) | 765 (8.7%) | 64 (2.6%) | 1066 (7.5%) |
Missing among ≤6 year olds | 232 (7.6%) | 607 (6.9%) | 221 (9.1%) | 1060 (7.4%) |
Absolute Change in FEV1 % Predicted Between Baseline and Index | ||||
Not Applicable <6 years old | 663 (21.7%) | 1631 (18.6%) | 199 (8.2%) | 2493 (17.5%) |
Increase | 499 (16.3%) | 1260 (14.4%) | 268 (11.0%) | 2027 (14.2%) |
0 - <10% decrease | 1100 (36.0%) | 3145 (35.8%) | 901 (37.0%) | 5146 (36.1%) |
≥10% decrease | 400 (13.1%) | 1685 (19.2%) | 695 (28.6%) | 2780 (19.5%) |
Missing among ≥6 year olds | 397 (13.0%) | 1053 (12.0%) | 369 (15.2%) | 1819 (12.8%) |
Microbiology (≥1 positive culture in year prior to Index) | ||||
Any culture performed in last year of care | 3,017 (98.6%) | 8,071 (99.2%) | 2,418 (99.4%) | 14,136 (99.1%) |
Pseudomonas aeruginosa | 1462 (48.5%) | 4129 (47.5%) | 1577 (65.2%) | 7168 (50.7%) |
Methicillin-resistant Staphylococcus aureus | 341 (11.3%) | 1287 (14.8%) | 316 (13.1%) | 1944 (13.8%) |
Other bacteria, including NTM | 1058 (35.1%) | 2983 (34.3%) | 489 (20.2%) | 4530 (32.0%) |
Negative cultures | 156 (5.2%) | 302 (3.5%) | 36 (1.5%) | 494 (3.5%) |
ABPA | 138 (4.5%) | 318 (3.6%) | 127 (5.2%) | 583 (4.1%) |
Prior-year IV-treated PEx | ||||
0 | 1996 (65.3%) | 5679 (64.7%) | 806 (33.1%) | 8481 (59.5%) |
1 | 582 (19.0%) | 1864 (21.2%) | 650 (26.7%) | 3096 (21.7%) |
2 | 234 (7.6%) | 697 (7.9%) | 367 (15.1%) | 1298 (9.1%) |
≥3 | 247 (8.1%) | 534 (6.1%) | 609 (25.0%) | 1390 (9.7%) |
PEX within 90 days of baseliine | 524 (17.1%) | 1349 (15.4%) | 753 (31.0%) | 2626 (18.4%) |
Treatment with IV antibiotics defined as any treatment within 14 days of Index clinic visit
Missing = 531