Effect of FPX on markers of leukocyte and complement activation. (A) Myeloperoxidase (MPO), (B) Citrullinated histone H3, (C) complement activation product C3b, (D) complement terminal complex C5b-9, and (E) high mobility group box 1 (HMGB1) in septic baboons without (LD100) or with FPX treatment (LD100+ FPX). Data are presented as mean ± SEM. For all graphs, asterisks indicate a statistically significant difference between LD100 and LD100+FPX, as calculated with the linear mixed effects model (*P < 0.05, **P <0.01, ***P < 0.001).