(A) Gentamicin: the burns treated with 1000 × MIC gentamicin hydrogel exhibited the highest re-epithelialization percentage on day 7 post-burn. The difference between topical gentamicin and empty PWD (p = 0.0241) as well as between IV gentamicin was statistically significant (p = 0.0130). (B) Minocycline: the burns treated with 1000 × MIC minocycline hydrogel had the highest re-epithelialization percentage in comparison to the other groups; however, no statistically significant differences were observed. (C) Vancomycin: the burns treated with 1000 × MIC vancomycin hydrogel were re-epithelialized more than the other groups, but no statistically significant differences were observed. Comparison of groups was performed using t-test, and p-values <0.05 were considered statistically significant (*0.01 p < 0.05, 0.001 p < 0.01, 0.0001 p < 0.001, p < 0.0001).