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. 2020 Jan;190(1):158–175. doi: 10.1016/j.ajpath.2019.09.023

Figure 8.

Figure 8

Gao-binge alcohol increases hepatic and circulating fibroblast growth factor 21 (Fgf21) in both WT and A-Atg5 KO mice. A-Atg5 KO mice and matched Cre− (WT) mice were subjected to Gao-binge alcohol treatment. A: Total liver lysates were subjected to Western blot analysis. B: Densitometry of A. C: Serum Fgf21 levels were measured by enzyme-linked immunosorbent assay. D: Livers were subjected to RNA extraction and real-time quantitative PCR. Data are expressed as means ± SEM (B–D). n = 3 to 4 (B); n = 8 to 13 (C); n = 4 to 5 (D). *P < 0.05 (one-way analysis of variance). ETOH, ethanol.