SGSH Activity in Brain Slices of MPS IIIA Mice at 12 and 25 Weeks Post-injection
SGSH activity was measured in individual brain slices 1, 3, and 5 according to the map given in Figure 1. Mouse #225 (17-week-old male in MPS IIIA low-dose group) was an outlier in each assay, exhibiting no increase in SGSH activity (compare with MPS IIIA vehicle mice). In the 30-week cohort, male low dose-treated MPS IIIA mice #422, #383, and #448 were outliers, exhibiting no increase in SGSH activity (compare with MPS IIIA vehicle mice). *p < 0.05, **p < 0.01, ****p < 0.0001 calculated from one-way ANOVA with Bonferroni’s multiple comparisons test.