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. 2019 Dec 10;17:174–187. doi: 10.1016/j.omtm.2019.12.001

Figure 2.

Figure 2

SGSH Activity in Brain Slices of MPS IIIA Mice at 12 and 25 Weeks Post-injection

SGSH activity was measured in individual brain slices 1, 3, and 5 according to the map given in Figure 1. Mouse #225 (17-week-old male in MPS IIIA low-dose group) was an outlier in each assay, exhibiting no increase in SGSH activity (compare with MPS IIIA vehicle mice). In the 30-week cohort, male low dose-treated MPS IIIA mice #422, #383, and #448 were outliers, exhibiting no increase in SGSH activity (compare with MPS IIIA vehicle mice). *p < 0.05, **p < 0.01, ****p < 0.0001 calculated from one-way ANOVA with Bonferroni’s multiple comparisons test.