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. 2019 Dec 10;17:174–187. doi: 10.1016/j.omtm.2019.12.001

Figure 3.

Figure 3

Total Amount of HS in Brain Slices of MPS IIIA Mice at 12 and 25 Weeks Post-injection

HS was quantified in individual brain slices 1, 3, and 5 according to the map given in Figure 1. Mouse #225 (17-week-old male in MPS IIIA low-dose group) was an outlier in each assay, exhibiting no reduction in HS (compare with MPS IIIA vehicle mice). In the 30-week cohort, male low dose-treated MPS IIIA mice #422, #383, and #448 were outliers, exhibiting no reduction in HS (compare with MPS IIIA vehicle mice). This is in keeping with the low amount of SGSH activity recorded for these mouse samples (Figure 2). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 calculated from one-way ANOVA with Bonferroni’s multiple comparisons test.