Figure 5.

Gadolinium Diffusion in Dog Brain

Representation of dog #109 that received four injections of 500 μL (two per hemisphere) of LYS-SAF302 with the MRI contrast agent gadolinium (5 mmol) into the white matter at 10 μL/min (total dose, 2.0E+12 vg). (A) Left lateral view of a dog brain with the position of coronal sections that include sites of injection. (B and C) MRI images of coronal rostral (B) and caudal (C) sections before injection with planned site of injection represented with red dot spots. (D and E) MRI images of coronal rostral (D) and caudal (E) sections after injection with gadolinium signal visible into the white matter. (F) Anterior view of 3D reconstruction of MRI images with gadolinium signal visible in both hemispheres along the rostro-caudal axis of the white matter. Scale bars, 10 mm.