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. 2019 Dec 10;17:174–187. doi: 10.1016/j.omtm.2019.12.001

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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SGSH Activity Distribution in NHP Brain

Representation of SGSH activity in the brain of two NHPs that received four injections of 50 μL (two per hemisphere) of LYS-SAF302 into the white matter at 5 μL/min (total dose, 7.2E+11 vg). (A) Left lateral view of a NHP brain with the location of the hemi-coronal brain slices shown. Rostral injections were between slices 4 and 6 and caudal injections were between slices 8 and 10. (B and C) A greater than 20% increase of SGSH activity relative to vehicle-injected control was observed 6 weeks after injection in 99% of the brain punches analyzed for NHP #169I (B) and 94% of the brain punches analyzed for NHP #763E (C). Numerical data are presented in Figure S10.