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. 2019 Dec 23;30:101412. doi: 10.1016/j.redox.2019.101412

Fig. 8.

Fig. 8

Schematic illustration of the proposed role of NRF2 in hepatocytes in HFD-induced NAFLD. Following a prolonged HFD exposure, the two genotypes of mice displayed different liver mass and TG accumulation in the liver. A possible mechanism is that NRF2 in hepatocyte is responsible for the expression of PPARγ to positively regulate lipid accumulation. Ablation of Nrf2 in hepatocytes results in down-regulation of PPARγ expression and subsequent reduction of lipid accumulation in the cells. The key findings in the present study demonstrate an essential role of NRF2 in the initiation of NAFLD via PPARγ expression.