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. 2019 Nov 27;14(6):553–559. doi: 10.1016/j.jtumed.2019.10.002

Figure 2.

Figure 2

Effects of acute diclofenac toxicity (200 mg/kg intraperitoneally) and ADE (2 g/kg orally) on lung histology: A: Group 1 is the negative control. Lung sections showing normal histology (normal alveolar capillaries (Black arrows), thin alveolar walls (White notched arrow), and clear alveoli (star) in group 1. B: Group 2 received Ajwa alone (ADE 2 g/kg orally). C: Group 3 displays acute diclofenac toxicity, including congested alveolar capillaries and alveolar haemorrhage (Black arrows), thick edematous alveolar walls (White notched arrow), and edema fluid exudates in the alveoli (Star). There is lung tissue infiltration by inflammatory cells (lightning bolt) and haemosedrine laden macrophages (Chevron). D: Group 4: Treatment of acute diclofenac toxicity using ADE daily for 4 consecutive days significantly mitigated all diclofenac-induced pathological changes in the lung. H&E staining and 400× magnification. Scale bar = 25 μm.