Table 2.
Associations Between Clinicopathological Parameters and the Mutational Status of Several Genes.
| EGFR |
IDH1/2 |
NF1 |
PTEN |
TERT |
TP53 |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| wt | mut | p | wt | Mut | p | wt | mut | p | wt | mut | p | wt | mut | p | wt | mut | p | ||
| Age | Median (minimum–maximum) | 54.6 (21.3–77.9) | 59.0 (40.8–78.2) | 0.209 | 56.2 (21.3–78.2) | 43.2 (25.2–62.9) | 0.001 | 54.4 (21.3–78.2) | 62.7 (45.9–73.8) | 0.064 | 54.5 (21.3–78.2) | 57.1 (53.4–65.7) | 0.423 | 46.5 (21.3–74.1) | 57.7 (33.0–78.2) | <0.001 | 54.6 (23.1–78.2) | 59.0 (21.3–77.9) | 0.805 |
| Ki67 | Median (minimum–maximum) | 17.0 (0–80.0) | 25.0 (0.5–70.0) | 0.538 | 18.0 (0–70.0) | 15.0 (1.5–80.0) | 0.961 | 18.0 (0–80.0) | 16.0 (3.0–20.0) | 0.279 | 18.0 (0–80.0) | 25.0 (8.0–35.0) | 0.675 | 16.5 (0–75.0) | 18 (0–80.0) | 0.802 | 18.0 (0–70.0) | 18.0 (0–80.0) | 0.984 |
| Tumor grade | III | 15 (17.4) | 1 (6.7) | 0.292 | 6 (6.9) | 10 (71.4) | <0.001 | 16 (17.0) | 0 (0.0) | 0.234 | 16 (16.8) | 0 (0.0) | 0.273 | 7(26.9) | 9(12.0) | 0.073 | 8 (10.5) | 8 (32.0) | 0.011 |
| IV | 71 (82.6) | 14 (93.3) | 81 (93.1) | 4 (28.6) | 78 (83.0) | 7 (100.0) | 79 (83.2) | 6 (100.0) | 19(73.1) | 66(88.0) | 68 (89.5) | 17 (68.0) | |||||||
| Sex | Female | 33 (38.4) | 9 (60.0) | 0.117 | 38 (43.7) | 4 (28.6) | 0.287 | 40 (42.6) | 2 (28.6) | 0.469 | 38 (40.0) | 4 (66.7) | 0.199 | 9(34.6) | 33(44.0) | 0.403 | 29 (38.2) | 13 (52.0) | 0.223 |
| Male | 53 (61.6) | 6 (40.0) | 49 (56.3) | 10 (71.4) | 54 (57.4) | 5 (71.4) | 57 (60.0) | 2 (33.3) | 17(65.4) | 42(56.0) | 47 (61.8) | 12 (48.0) | |||||||
| Type of surgery | Biopsy/stereotactic biopsy | 19 (23.2) | 4 (28.6) | 0.892 | 18 (21.7) | 5 (38.5) | 0.368 | 21 (23.6) | 2 (28.6) | 0.553 | 20 (22.2) | 3 (50.0) | 0.256 | 9(36.0) | 14(19.7) | 0.119 | 18 (25.0) | 5 (20.8) | 0.835 |
| Subtotal | 52 (63.4) | 8 (57.1) | 54 (65.1) | 6 (46.2) | 55 (61.8) | 5 (71.4) | 58 (64.4) | 2 (33.3) | 15(60.0) | 45(63.4) | 45 (62.5) | 15 (62.5) | |||||||
| Total excision | 11 (13.4) | 2 (14.3) | 11 (13.3) | 2 (15.4) | 13 (14.6) | 0 (0.0) | 12 (13.3) | 1 (16.7) | 1(4.0) | 12(16.9) | 9 (12.5) | 4 (16.7) | |||||||
| Necrosis | No | 18 (20.9) | 1 (6.7) | 0.192 | 10 (11.5) | 9 (64.3) | <0.001 | 19 (20.2) | 0 (0.0) | 0.187 | 19 (20.0) | 0 (0.0) | 0.224 | 9(34.6) | 10(13.3) | 0.017 | 12 (15.8) | 7 (28.0) | 0.175 |
| Yes | 68 (79.1) | 14 (93.3) | 77 (88.5) | 5 (35.7) | 75 (79.8) | 7 (100.0) | 76 (80.0) | 6 (100.0) | 17(65.4) | 65(86.7) | 64 (84.2) | 18 (72.0) | |||||||
| Hemorrhage | No | 20 (23.3) | 3 (20.0) | 0.781 | 15 (17.2) | 8 (57.1) | 0.001 | 22 (23.4) | 1 (14.3) | 0.579 | 22 (23.2) | 1 (16.7) | 0.713 | 11(42.3) | 12(16.0) | 0.006 | 13 (17.1) | 10 (40.0) | 0.018 |
| Yes | 66 (76.7) | 12 (80.0) | 72 (82.8) | 6 (42.9) | 72 (76.6) | 6 (85.7) | 73 (76.8) | 5 (83.3) | 15(57.7) | 63(84.0) | 63 (82.9) | 15 (60.0) | |||||||
| Endothelial hyperplasia | No | 17 (19.8) | 1 (6.7) | 0.221 | 10 (11.5) | 8 (57.1) | <0.001 | 18 (19.1) | 0 (0.0) | 0.202 | 18 (18.9) | 0 (0.0) | 0.240 | 6(23.1) | 12(16.0) | 0.417 | 13 (17.1) | 5 (20.0) | 0.743 |
| Yes | 69 (80.2) | 14 (93.3) | 77 (88.5) | 6 (42.9) | 76 (80.9) | 7 (100.0) | 77 (81.1) | 6 (100.0) | 20(76.9) | 63(84.0) | 63 (82.9) | 20 (80.0) | |||||||
wt: wild-type; mut: mutated. P-values in bold indicate statistically significant results at the 5% level of significance.