Table 3.
Associations of the Mutational Status Between EGFR, IDH1/2, NF1, PTEN, TERT, and TP53.
| EGFR |
IDH1/2 |
NF1 |
PTEN |
TERT |
TP53 |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| mut | wt | p | mut | wt | p | mut | Wt | p | mut | wt | p | mut | wt | p | mut | wt | p | ||
| EGFR | wt | 0 (0.0) | 86 (100.0) | ||||||||||||||||
| mut | 15 (100.0) | 0 (0.0) | |||||||||||||||||
| IDH1/2 | wt | 14 (93.3) | 73 (84.9) | 0.382 | 0 (0.0) | 87 (100.0) | |||||||||||||
| mut | 1 (6.7) | 13 (15.1) | 14 (100.0) | 0 (0.0) | |||||||||||||||
| NF1 | wt | 12 (80.0) | 82 (95.3) | 0.031 | 14 (100.0) | 80 (92.0) | 0.271 | 0 (0.0) | 94 (100.0) | ||||||||||
| mut | 3 (20.0) | 4 (4.7) | 0 (0.0) | 7 (8.0) | 7 (100.0) | 0 (0.0) | |||||||||||||
| PTEN | wt | 12 (80.0) | 83 (96.5) | 0.013 | 13 (92.9) | 82 (94.3) | 0.838 | 5 (71.4) | 90 (95.7) | 0.009 | 0 (0.0) | 95 (100.0) | |||||||
| mut | 3 (20.0) | 3 (3.5) | 1 (7.1) | 5 (5.7) | 2 (28.6) | 4 (4.3) | 6 (100.0) | 0 (0.0) | |||||||||||
| TERT | wt | 2 (13.3) | 24 (27.9) | 0.234 | 7 (50.0) | 19 (21.8) | 0.025 | 1 (14.3) | 25 (26.6) | 0.472 | 1 (16.7) | 25 (26.3) | 0.600 | 0 (0.0) | 26 (100.0) | ||||
| mut | 13 (86.7) | 62 (72.1) | 7 (50.0) | 68 (78.2) | 6 (85.7) | 69 (73.4) | 5 (83.3) | 70 (73.7) | 75 (100.0) | 0 (0.0) | |||||||||
| TP53 | wt | 11 (73.3) | 65 (75.6) | 0.852 | 5 (35.7) | 71 (81.6) | <0.001 | 4 (57.1) | 72 (76.6) | 0.250 | 2 (33.3) | 74 (77.9) | 0.014 | 61 (81.3) | 15 (57.7) | 0.016 | 0 (0.0) | 76 (100.0) | |
| mut | 4 (26.7) | 21 (24.4) | 9 (64.3) | 16 (18.4) | 3 (42.9) | 22 (23.4) | 4 (66.7) | 21 (22.1) | 14 (18.7) | 11 (42.3) | 25 (100.0) | 0 (0.0) | |||||||
wt: wild-type; mut: mutated. P-values in bold indicate statistically significant results at the 5% level of significance.