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. 2020 Jan 2;51:102582. doi: 10.1016/j.ebiom.2019.11.043

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Expression of TRIM13 and CHOP in renal biopsies. (A) The mRNA and protein levels of TRIM13 in renal biopsies from DN patients and normal controls were measured by qRT-PCR and western blot analysis, respectively. (B) The correlation between TRIM13 mRNA and UACR, as well as TRIM13 mRNA and eGFR in renal biopsies of DN patients was analyzed by the Pearson's correlation test. (C) IHC and PAS staining and the IHC intensity analysis of TRIM13 protein in normal and DN biopsies. The scale bar represents 100 μm. Magnification is 400X. (D) The protein level of CHOP. (E) The correlation between TRIM13 protein level and CHOP protein level in renal biopsies from DN patients was analyzed by the Pearson's correlation test. (F) The mRNA levels of collagen-associated factors Col1a2, Col4a1, and TGF-β1. **P<0.01 vs. Normal. Three independent experiments and 10 samples were used in each examination (qRT-PCR, western blot analysis, and IHC/PAS staining). Normal, normal kidney biopsies. DN, kidney biopsies from diabetic nephropathy patients. UACR, urinary albumin-to-creatinine ratio. eGFR, estimated glomerular filtration rate. IHC, immunohistochemistry. NC, negative control.