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. 2020 Jan 2;51:102582. doi: 10.1016/j.ebiom.2019.11.043

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — Overexpressed TRIM13 restores renal function in DN mice. The db/db mice were randomly divided into 4 groups: Control, AAV-GFP, AAV-TRIM13, AAV-TRIM13+AAV-CHOP. AAV-TRIM13 and/or AAV-CHOP vectors were injected weekly via the renal vein for 12 weeks. (A) The UACR, BUN, and creatinine levels. (B) The TGF-β1 level in tissues was detected using ELISA. (C) PAS staining and morphometric analysis of renal glomeruli. Mesangial expansions were shown by black arrows. The scale bars represent 100 μm. Magnification is 400X. (D) Schema depicting the mechanisms of the involvement of TRIM13/CHOP axis in DN. *P<0.05, **P<0.01 vs. AAV-GFP; #P<0.05 vs. AAV-TRIM13. Three independent experiments. UACR, urinary albumin-to-creatinine ratio. AAV, adenovirus associated virus. DN, diabetic nephropathy. BUN, blood urea nitrogen.