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Pyruvate dehydrogenase complex (PDHC) modulation and oxygen consumption rate (OCR). HL-60 cells treated with PDT-BIPA for certain time were lysed for PDHC activity assays (A,B) and the expression of PDHC and PDH E2 were determined by ELISA kits (C,D). The OCR of intact cells was monitored following the addition of PDT-BIPA digitonin, NADH, or succinate (E). Cells were also incubated with PDT-BIPA for 24 h and treated in the same way as the intact cells (F).
