Figure 3.

The ROS bursting and its regulation. Different dosages of PDT-BIPA after 24-h exposure (A) or with or without BSO scavenging GSH, 2 µM PDT-BIPA exposure for different times (B) induces ROS augment. BSO could diminish the increasing level of GSH under 0.5 µM PDT-BIPA exposure (C). MK571 weakens the exclusion of arsenic where GSH is involved in (D). To scavenge the soaring ROS and exclude arsenic, GSH could recover the cell viability destroyed by PDT-BIPA (E). And also, the TrxR activity was reduced under high dosage of PDT-BIPA exposure as time went by (F). (G) The expression of TrxR.