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. 2019 Dec 16;20(24):6344. doi: 10.3390/ijms20246344

Figure 2.

Figure 2

Targeting transient receptor potential channels. Scheme depicting TRPA1, TRPV1, and TRPM8 channels and their partner proteins. Sigma-1 receptor (Sig-1R) activating partner protein is shown in green and inhibiting partner proteins such as calmodulin (CaM) and androgen receptor (AR) is shown in red. Steroids targeting these interactions are represented by triangles: red triangles indicate an inhibitory effect, green triangles an activating effect. PM, plasma membrane.