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. 2019 Dec 16;20(24):6344. doi: 10.3390/ijms20246344

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Targeting the store-operated calcium entry. Scheme depicting the Orai1 channel (in purple) and Stim1 (in pink) and their partner proteins. Activating partner proteins are shown in green, inhibiting partner proteins in red. Molecules targeting the partners are represented by triangles: red triangles indicate an inhibitory effect, green triangles an activating effect. PM, plasma membrane; ER, endoplasmic reticulum; CRACR2a, calcium release activated calcium channel regulator 2a; SPCA2, secretory pathway calcium ATPase 2; STIMATE, Stim-activating enhancer.