Figure 4.

Sex differences of dopamine clearance rate in MP mice. DA reuptake efficacy (a) following tonic stimulation in striatum is less in male than female MP mice at eight, nine, and 10 weeks. At 11 weeks there is no gender difference. (b) With phasic stimulation, the male and female MP mice differ at 9 and 10 weeks. In NAc shell (c) tonic (1 P) and (d) phasic (10 P) stimulation does not reveal any gender differences. (e) PET imaging using the DA transporter ligand [¹⁸F]FE-PEI in striatum does not reveal gender differences in WT mice. (f) PET shows that the binding of the DA transporter ligand in striatum differs significantly between genders in six-week old MP mice and a similar trend is seen at later ages. The value of the WT group is the average from adult and aging mice. Two-way analysis of variance (ANOVA) followed by a Bonferroni post hoc test for multiple comparisons; * p < 0.05, ** p < 0.01, *** p < 0.001 MitoPark_Female vs. MitoPark_Male; # p < 0.05, ## p < 0.01, ### p < 0.001 WT vs. MitoPark_Female; $ p < 0.05, $$ p < 0.01, $$$ p < 0.001 WT vs. MitoPark_Male.