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. 2019 Dec 9;20(24):6208. doi: 10.3390/ijms20246208

Table 1.

Description of materials used for cell-electrospinning classified into natural and synthetic polymers.

Biomaterial Description Advantages Disadvantages
Natural polymer Collagen [42,43,44] Most abundant protein in mammals
Main protein of extracellular matrix (ECM)
Mostly found in tendons, ligaments, bone and skin tissue
Highly biocompatible and biodegradable
Relatively nonimmunogenic
Poor mechanical strength
Expensive
Gelatin [45,46] Derived from collagen
Similar properties with collagen
Biocompatible and biodegradable
Relatively low cost
Poor mechanical strength
Alginate [47,48,49] Derived from cell walls of brown algae
Natural polysaccharide
Biocompatible and biodegradable
Adequate crosslinking capacity
Relatively low cost
Non-toxicity
Poor mechanical strength without crosslinking
Low biological properties
Synthetic polymer Poly(dimethylsiloxane) (PDMS) [50,51,52] Silicon-based organic polymer Non-toxic and inert
Viscoelastic
Homogeneous and isotropic
Lacks in bio-functional cues
Polyvinyl alcohol (PVA)
[53,54,55]
Water-soluble synthetic polymer High solubility and biodegradability
Relatively low cost
Long-lasting durability
High temperature stability
Lacks in bio-functional cues