Table 1.

Humanized mice with antigen-specific antibody production.

Mouse Strain.		Transplanted Tissues	Antigen	Isotype	Reference
SCID-Hu	SCID	human fetal liver and thymic fragments under kidney capsule	pneumococcal vaccine	IgG	McCune JM 1988 [117], Aaberge IS et al., 1992 [118]
Hu-HSC	NOG	HSC(CB/MPB/BM) i.v.	DNP-KLH/CH401MAP/TSST-1	IgM	Matsumura T et al., 2003 [109], Kametani Y et al., 2006 [114]
	NSG; Balb/c-Rag1(-/-) gammac(-/-); C.B-17-scid/bg	HSC(CB/MPB/HFL) i.v.	KLH/inactivated H5N1 influenza virus	IgM, IgG	Lepus CM et al., 2009 [111]
	NOG	CD34 + HSC i.v.	OVA	Igs	Yajima M et al., 2008 [98], Watanabe Y et al., 2009 [112]
	NSG	human CD34 + HSC i.v.	OVA, HIV	IgM, IgG	Wtanabe S et al., 2007 [110], Singh M et al., 2012 [102]
	NOG-HLA-DR4/Ab KO	human CD34 + HSC i.v.	OVA	IgM, IgG	Suzuki M et al., 2012 [119]
	NSG-HIS-CD4/B	human CD34 + HSC i.v.	Plasmodium falciparum, circumsporo-zoite (PFCS) protein	IgG	Huang J et al., 2015 [120]
Hu-PBL	SCID	human PBMC i.v.	xenograft	IgM, IgG	Williams S et al., 1992 [121]
	NOG-IL-4-Tg	human PBMC i.v.	KLH/CH401MAP	IgG	Kametani Y et al., 2017 [116]
	DKO-NOG	human PBMC i.v.	human Liver xenograft,	Igs	Aono S et al. 2018 [122]
BLT	SCID	human fetal liver and thymic fragments under kidney capsule with autologous CD34 + HSC		IgG	McCune JM et al., 1988 [123], Aaberge IS et al., 1992 [118]
	NOD-SCID	human fetal liver and thymic fragments under kidney capsule with autologous CD34 + HSC	HIV-1, WNV envelope protein	IgM, IgG	Biswas et al., 2011 [113]
	NSG	human fetal liver and thymic fragments under kidney capsule with autologous CD34 + HSC	pneumococcal vaccine, Dengue virus infection, Zika virus, HIV -1 gp120	IgM, IgG, IgA	Jaiswal S et al., 2015 [124], Jangalwe S et al., 2016 [125], Schmitt K et al., 2018 [126], Gawron MA et al., 2019 [127]

Representative immune-humanized mouse systems which induced antibody production are shown. The data are based on PubMed, published from 1988 to 2019.