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. 2019 Dec 7;20(24):6186. doi: 10.3390/ijms20246186

Figure 2.

Figure 2

Skin disease-associated Cx43 mutations generate large hemichannel currents within transfected N2a cells (A). Single cells were measured using whole-cell patch-clamp technique, with a holding potential of 0 mV. Membrane current responses to voltage pulses were recorded between −90 to +90 mV at 10 mV increments. Untransfected (B) and wild-type Cx43 (C) expressing cells exhibited small membrane currents. Cx43-A44V (D) and Cx43-E227D (E) expressing N2A cells displayed larger hemichannel currents compared to the wild-type.