Table 3.

The prevalence of glomerular IgA deposition in kidney donors and necropsy cases.

Sample Size (Population)	Mesangial Deposition	Positive Cases	Clinical or Histological Features of Cases with IgA Deposits	Ref
Primary glomerular IgA deposition in individuals without clinical manifestation of renal disease
510 kidney transplant cases (64 cadaveric and 446 living donors) (Japanese donors)	IgA IgA + C3	82/510 (16%) 16/82	IgA + C3 deposition was associated with mild degree of microhematuria, mesangial proliferation, and glomerular macrophage infiltration	[38]
756 autopsy cases (violent death) (Finland)	IgA IgA + C3b IgA + C1q IgA + IgG	52/756 (6.8%) 4/52 2/52 8/52	10/52 cases had morphological changes suggestive of renal disease	[39]
200 autopsy cases (violent death) (Singapore)	IgA IgA + C3b IgA + C1q IgA + IgG	8/200 (4%) 2/8 0/8 4/8	Histology revealed only minimal morphological alterations	[40]
Secondary glomerular IgA deposition
250 consecutive autopsy cases (non-selected) (Germany)	IgA IgA + C3 IgA + C5 IgA + IgG(+)	12/250 (4.8%) 1/6 5/6 2/6	6/12 associated with liver cirrhosis 6/12 associated with endocarditis, bronchial asthma, cardiovascular disease, or neoplasia; IgA1+, IgA2 (+), SC (+)	[41]