Table 4.
Heritability of serum Gd-IgA1 found in hereditary studies.
| Sample Population | Controls Healthy Unrelated | Ancestry of Patients | Heritability (P Value) | Ref |
|---|---|---|---|---|
| 89 adult IgAN patients vs. 266 blood relatives | 150 adults | European | 0.54 (0.0001) |
[46] |
| 63 adult IgAN patients vs. 32 first-degree relatives | 44 adults | Chinese Asian | Yes nd |
[48] |
| 11 pediatric and 18 adult IgAN patients vs. 34 first-degree relatives | 45 pediatric (European) 150 adult (European) |
African American | 0.74 (0.007) |
[47] |
| 14 pediatric IgAN patients vs. 25 first-degree relatives | 51 pediatric 141 adults |
European | 0.76 (<0.05) |
[49] |
| 134 adult IgAN trios | 638 adults | UK whites | 0.387 (<0.05) | [45] |
| 20 pediatric HSPN patients vs. 28 first-degree relatives | 51 pediatric 141 adults |
European | 0.64 (<0.05) |
[49] |
| 27 monozygotic healthy female twin pairs 47 dizygotic healthy female twin pairs |
European (UK) | 0.84 0.46 (<0.05) |
[50] | |
Legend: nd: not determined; HSPN: Henoch–Schönlein purpura nephritis. Increased levels of Gd-IgA1 in all above studies (except one [48]) were defined as levels that are 75% or 90% or 95% greater than the levels observed in geographically matched healthy controls.