Table 5.
Genome-wide association studies (GWAS) and identified loci associated with IgAN.
| GWAS | Sample Population | Ancestry of Patients | Identified Loci | IgAN Risk |
|---|---|---|---|---|
| [52] | 914 cases vs. 5069 controls | European | 6p–HLA-B, DRB1, DQA, DQB | nr |
| [53] | 3144 cases vs. 2822 controls | Chinese, European | 1q32-CFHR1, CFHR3; 22q12.2–OSM, LIF, HORMAD2, MTMR3; 6p21–HLA-DRB1, HLA-DQB1, HLA-DPA1, HLA-DPB1, HLA-DPB2, TAP2, TAP1, PSMB8, PSMB9 |
4–7% |
| [54] | 4137 cases vs. 7734 controls | Chinese | 8p23–DEFA, 17p13-TNFSF13; 22q12–HORMAD2 | nr |
| [55] | 7658 cases vs. 12,954 controls | European, East Asian | 1p13-VAV3; 9q34–CARD9; 16p11-ITGAM, ITGAX; 8p23–DEFA; 6p21–HLA-DQ-HLA-DR, TAP1–PSMB8 and HLA-DP; 1q32-CFHR1, CFHR3; 17p13-TNFSF13; 22q12–HORMAD2 | 5% |
| [56] | 8313 cases vs. 19,680 controls | Chinese | 3q27.3-ST6GAL1; 8p23–DEFA; 11p11.2-ACCS; 8q22.3-ODF1-KLF10; 16p11-ITGAM, ITGAX |
1.7% 5% |
| [57] | 2633 cases | European, East Asian | Xq24-C1GALT1C1; 7p21.3-C1GALT1 | 7% 2% |
| [58] | 915 patients vs. 481 controls | Japanese | 6p21–HLA locus; 12q12–TSPAN8-PTPRR locus | nr |
| [59] | 498 patients vs. 893 controls | Koreans | 10p15.1-ANKRD16 | nr |