EVs	Extracellular vesicles
CYP	Cytochrome P450
CPR	CYP reductase
APAP	Acetaminophen
ROS	Reactive oxygen species
CSF	Cerebral spinal fluid
Bap	Benzo(a)pyrene
PAH	Polycyclic aromatic hydrocarbon
NNK	Nicotine-derived nitrosamine ketone
CSC	Cigarette smoke condensate
ADH	Alcohol dehydrogenase
BBB	Blood-brain barrier
CNS	Central nervous system
HAND	HIV-associated neurocognitive disorders
PD	Parkinson’s disease
MVBs	Micro-vesicular bodies
ALT	Alanine aminotransferase
AST	Aspartate aminotransferase
GDEPT	Gene-directed enzyme prodrug therapy
CPA	Cyclophosphamide
IFA	Ifosfamide