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. 2019 Dec 10;20(24):6223. doi: 10.3390/ijms20246223

Figure 2.

Figure 2

Chimeric antigen receptor (CAR) design. CARs consist of a single chain variable fragment (scFv) of an antibody, a non-signaling extracellular spacer and hinge domain, a transmembrane (TM) domain, an intracellular CD3ζ signaling domain from the T cell receptor and a costimulatory domain.